Moderate influenza vaccine effectiveness against hospitalisation with A(H3N2) and A(H1N1) influenza in 2013–14: Results from the InNHOVE network
Identifieur interne : 000067 ( France/Analysis ); précédent : 000066; suivant : 000068Moderate influenza vaccine effectiveness against hospitalisation with A(H3N2) and A(H1N1) influenza in 2013–14: Results from the InNHOVE network
Auteurs : M. Rondy ; J. Castilla ; O. Launay [France] ; S. Costanzo ; C. Ezpeleta ; F. Galtier [France] ; K. Gaetano DonatiSource :
- Human Vaccines & Immunotherapeutics [ 2164-5515 ] ; 2016-02-02.
English descriptors
Abstract
We conducted a multicentre test negative case control study to estimate the 2013–14 influenza vaccine effectiveness (IVE) against hospitalised laboratory confirmed influenza in 12 hospitals in France, Italy and Spain. We included all ≥18 years hospitalised patients targeted by local influenza vaccination campaign reporting an influenza-like illness within 7 days before admission. We defined as cases patients RT-PCR positive for influenza and as controls those negative for all influenza virus. We used a logistic regression to calculate IVE adjusted for country, month of onset, chronic diseases and age. We included 104 A(H1N1)pdm09, 157 A(H3N2) cases and 585 controls. The adjusted IVE was 42.8% (95%CI: 6.3;65;0) against A(H1N1)pdm09. It was respectively 61.4% (95%CI: −1.9;85.4), 39.4% (95%CI: −32.2;72.2) and 19.7% (95%CI:-148.1;74.0) among patients aged 18–64, 65–79 and ≥80 years. The adjusted IVE against A(H3N2) was 38.1% (95%CI: 8.3;58.2) overall. It was respectively 7.8% (95%CI: −145.3;65.4), 25.6% (95%CI: −36.0;59.2) and 55.2% (95%CI: 15.4;76.3) among patients aged 18–64, 65–79 and ≥80 years. These results suggest a moderate and age varying effectiveness of the 2013–14 influenza vaccine to prevent hospitalised laboratory-confirmed influenza. While vaccination remains the most effective prevention measure, developing more immunogenic influenza vaccines is needed to prevent severe outcomes among target groups. © 2016 Taylor & Francis.
Url:
DOI: 10.1080/21645515.2015.1126013
Affiliations:
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Gaetano Donati</name></author></analytic><idno type="DOI">10.1080/21645515.2015.1126013</idno><series><title level="j">Human Vaccines & Immunotherapeutics</title><idno type="ISSN">2164-5515</idno><imprint><date type="datePub">2016-02-02</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="mix" xml:lang="en"><term>Influenza</term><term>Influenza vaccine</term><term>case control studies</term><term>hospital</term><term>multicentre studies</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"> <p>We conducted a multicentre test negative case control study to estimate the 2013–14 influenza vaccine effectiveness (IVE) against hospitalised laboratory confirmed influenza in 12 hospitals in France, Italy and Spain. We included all ≥18 years hospitalised patients targeted by local influenza vaccination campaign reporting an influenza-like illness within 7 days before admission. 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While vaccination remains the most effective prevention measure, developing more immunogenic influenza vaccines is needed to prevent severe outcomes among target groups. © 2016 Taylor & Francis.</p> </div></front></TEI><affiliations><list><country><li>France</li></country></list><tree><noCountry><name sortKey="Castilla, J" sort="Castilla, J" uniqKey="Castilla J" first="J." last="Castilla">J. Castilla</name><name sortKey="Costanzo, S" sort="Costanzo, S" uniqKey="Costanzo S" first="S." last="Costanzo">S. Costanzo</name><name sortKey="Ezpeleta, C" sort="Ezpeleta, C" uniqKey="Ezpeleta C" first="C." last="Ezpeleta">C. Ezpeleta</name><name sortKey="Gaetano Donati, K" sort="Gaetano Donati, K" uniqKey="Gaetano Donati K" first="K." last="Gaetano Donati">K. Gaetano Donati</name><name sortKey="Rondy, M" sort="Rondy, M" uniqKey="Rondy M" first="M." last="Rondy">M. Rondy</name></noCountry><country name="France"><noRegion><name sortKey="Launay, O" sort="Launay, O" uniqKey="Launay O" first="O." last="Launay">O. Launay</name></noRegion><name sortKey="Galtier, F" sort="Galtier, F" uniqKey="Galtier F" first="F." last="Galtier">F. Galtier</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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